The safe use of food additives in Canada (including those using nanomaterials) is ensured by the Food Directorate´s Bureau of Chemical Safety by completing a pre-market evaluation of these substances pursuant to the pre-clearance requirements of Section B.16.002 of the Food and Drug Regulations. In order for a food additive to be approved, the manufacturer must prepare a submission package containing all required information so that a thorough safety assessment can be initiated. Submission from the manufacturer may include petition for the approval of new additives (including those containing nanomaterials) or extensions of use of previously approved additives. Approval is granted provided that the safety/efficacy data meet the requirements for the intended use of the food additive [http://www.hc-sc.gc.ca/fn-an/securit/addit/index-eng.php]. Upon approval, an enabling amendment is developed according to federal regulatory process and the new food additive is added to the food additive tables in Division 16 of the Regulation.